Homologous recombination deficiency signatures in gastrointestinal and thoracic cancers correlate with platinum therapy duration

Homologous recombination deficiency signatures in gastrointestinal and thoracic cancers correlate with platinum therapy duration

Abstract There is emerging evidence about the predictive role of homologous recombination deficiency (HRD), but this is less defined in gastrointestinal (GI) and thoracic malignancies. We reviewed whole genome (WGS) and transcriptomic (RNA-Seq) data from advanced GI and thoracic cancers in the Perso...

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Dades bibliogràfiques
Autors principals: Erica S. Tsang, Veronika Csizmok, Laura M. Williamson, Erin Pleasance, James T. Topham, Joanna M. Karasinska, Emma Titmuss, Intan Schrader, Stephen Yip, Basile Tessier-Cloutier, Karen Mungall, Tony Ng, Sophie Sun, Howard J. Lim, Jonathan M. Loree, Janessa Laskin, Marco A. Marra, Steven J. M. Jones, David F. Schaeffer, Daniel J. Renouf
Format: Article
Idioma:English
Publicat: Nature Portfolio 2023-03-01
Col·lecció:npj Precision Oncology
Accés en línia:https://doi.org/10.1038/s41698-023-00368-x

Internet

https://doi.org/10.1038/s41698-023-00368-x

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