Apelin-13 Protects Dopaminergic Neurons against Rotenone—Induced Neurotoxicity through the AMPK/mTOR/ULK-1 Mediated Autophagy Activation

Apelin-13 Protects Dopaminergic Neurons against Rotenone—Induced Neurotoxicity through the AMPK/mTOR/ULK-1 Mediated Autophagy Activation

Parkinson’s disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Several brain–gut peptides are able to exert neuroprotective effects on the nigrostriatal dopaminergic system. Apelin-13 is a neuropeptide, conveying potential neuroprotec...

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Bibliographic Details
Main Authors: Peng Chen, Youcui Wang, Leilei Chen, Ning Song, Junxia Xie
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
Parkinson’s disease
neuroprotection
apelin-13
autophagy
AMPK/mTOR/ULK-1 signaling
Online Access:https://www.mdpi.com/1422-0067/21/21/8376

Internet

https://www.mdpi.com/1422-0067/21/21/8376

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