An ancient Pygo-dependent Wnt enhanceosome integrated by Chip/LDB-SSDP
TCF/LEF factors are ancient context-dependent enhancer-binding proteins that are activated by β-catenin following Wnt signaling. They control embryonic development and adult stem cell compartments, and their dysregulation often causes cancer. β-catenin-dependent transcription relies on the NPF motif...
Main Authors: | Marc Fiedler, Michael Graeb, Juliusz Mieszczanek, Trevor J Rutherford, Christopher M Johnson, Mariann Bienz |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2015-08-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/09073 |
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