Epigallocatechin-3-Gallate Plus Omega-3 Restores the Mitochondrial Complex I and F<sub>0</sub>F<sub>1</sub>-ATP Synthase Activities in PBMCs of Young Children with Down Syndrome: A Pilot Study of Safety and Efficacy

Epigallocatechin-3-Gallate Plus Omega-3 Restores the Mitochondrial Complex I and F<sub>0</sub>F<sub>1</sub>-ATP Synthase Activities in PBMCs of Young Children with Down Syndrome: A Pilot Study of Safety and Efficacy

Down syndrome (DS) is a major genetic cause of intellectual disability. DS pathogenesis has not been fully elucidated, and no specific pharmacological therapy is available. DYRK1A overexpression, oxidative stress and mitochondrial dysfunction were described in trisomy 21. Epigallocatechin-3-gallate...

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Bibliographic Details
Main Authors: Iris Scala, Daniela Valenti, Valentina Scotto D’Aniello, Maria Marino, Maria Pia Riccio, Carmela Bravaccio, Rosa Anna Vacca, Pietro Strisciuglio
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Antioxidants
Subjects:
nutraceutical supplementation
Down syndrome
mitochondrial dysfunction
EGCG
developmental profiling
clinical study
Online Access:https://www.mdpi.com/2076-3921/10/3/469

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https://www.mdpi.com/2076-3921/10/3/469

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