The COX- inhibitor indomethacin reduces Th1 effector and T regulatory cells in vitro in Mycobacterium tuberculosis infection

The COX- inhibitor indomethacin reduces Th1 effector and T regulatory cells in vitro in Mycobacterium tuberculosis infection

Abstract Background Tuberculosis (TB) causes a major burden on global health with long and cumbersome TB treatment regimens. Host-directed immune modulating therapies have been suggested as adjunctive treatment to TB antibiotics. Upregulated cyclooxygenase-2 (COX-2)-prostaglandin E2 (PGE2) signaling...

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Bibliographic Details
Main Authors: Kristian Tonby, Ida Wergeland, Nora V. Lieske, Dag Kvale, Kjetil Tasken, Anne M. Dyrhol-Riise
Format: Article
Language:English
Published: BMC 2016-10-01
Series:BMC Infectious Diseases
Subjects:
Tuberculosis
COX-inhibitors
Tregs
Regulatory T cells
Host-directed therapy
Monocytes
Online Access:http://link.springer.com/article/10.1186/s12879-016-1938-8

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http://link.springer.com/article/10.1186/s12879-016-1938-8

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