The crosstalk between MYC and mTORC1 during osteoclastogenesis

The crosstalk between MYC and mTORC1 during osteoclastogenesis

Osteoclasts are bone-resorbing cells that undergo extensive changes in morphology throughout their differentiation. Altered osteoclast differentiation and activity lead to changes in pathological bone resorption. The mammalian target of rapamycin (mTOR) is a kinase, and aberrant mTOR complex 1 (mTOR...

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Bibliographic Details
Main Authors: Seyeon Bae, Brian Oh, Jefferson Tsai, Peter Sang Uk Park, Matthew Blake Greenblatt, Eugenia G. Giannopoulou, Kyung-Hyun Park-Min
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
MYC (c-myc)
GADD34 (PPP1R15A)
osteoclast (OC)
mTORC1 (mechanistic target of rapamycin complex 1)
bone resorption
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.920683/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.920683/full

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