Single cell proteogenomic sequencing identifies a relapse‐fated AML subclone carrying FLT3‐ITD with CN‐LOH at chr13q

Single cell proteogenomic sequencing identifies a relapse‐fated AML subclone carrying FLT3‐ITD with CN‐LOH at chr13q

Abstract Internal tandem duplication of the Feline McDonough Sarcoma (FMS)‐like tyrosine kinase 3 (FLT3‐ITD) is one of the most clinically relevant mutations in acute myeloid leukemia (AML), with a high FLT3‐ITD allelic ratio (AR) (≥0.5) being strongly associated with poor prognosis. FLT3‐ITDs are h...

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Bibliographic Details
Main Authors: TaeHyung Kim, Hyewon Lee, Jose‐Mario Capo‐Chichi, Myung Hee Chang, Young Seok Yoo, Gurbaksh Basi, Troy Ketela, Adam C. Smith, Anne Tierens, Zhaolei Zhang, Mark D. Minden, Dennis Dong Hwan Kim
Format: Article
Language:English
Published: Wiley 2022-05-01
Series:eJHaem
Subjects:
AML
molecular diagnostics
prognostic factors
single cell
Online Access:https://doi.org/10.1002/jha2.390

Internet

https://doi.org/10.1002/jha2.390

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