Identifying foetal forebrain interneurons as a target for monogenic autism risk factors and the polygenic 16p11.2 microdeletion

Identifying foetal forebrain interneurons as a target for monogenic autism risk factors and the polygenic 16p11.2 microdeletion

Abstract Background Autism spectrum condition or ‘autism’ is associated with numerous genetic risk factors including the polygenic 16p11.2 microdeletion. The balance between excitatory and inhibitory neurons in the cerebral cortex is hypothesised to be critical for the aetiology of autism making imp...

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Bibliographic Details
Main Authors: Yifei Yang, Sam A. Booker, James M. Clegg, Idoia Quintana-Urzainqui, Anna Sumera, Zrinko Kozic, Owen Dando, Sandra Martin Lorenzo, Yann Herault, Peter C. Kind, David J. Price, Thomas Pratt
Format: Article
Language:English
Published: BMC 2023-01-01
Series:BMC Neuroscience
Subjects:
Development
Telencephalon
Autism
Genetics
Single cell transcriptomics
GABAergic
Online Access:https://doi.org/10.1186/s12868-022-00771-3

Internet

https://doi.org/10.1186/s12868-022-00771-3

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