Illumination of Molecular Pathways in Multiple Sclerosis Lesions and the Immune Mechanism of Matrine Treatment in EAE, a Mouse Model of MS

Illumination of Molecular Pathways in Multiple Sclerosis Lesions and the Immune Mechanism of Matrine Treatment in EAE, a Mouse Model of MS

The etiology of multiple sclerosis (MS) is not clear, and the treatment of MS presents a great challenge. This study aimed to investigate the pathogenesis and potential therapeutic targets of MS and to define target genes of matrine, a quinolizidine alkaloid component derived from the root of Sophor...

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Príomhchruthaitheoirí:	Mengmeng Dou, Xueliang Zhou, Lifeng Li, Mingliang Zhang, Wenbin Wang, Mengru Wang, Yilei Jing, Rui Ma, Jie Zhao, Lin Zhu
Formáid:	Alt
Teanga:	English
Foilsithe / Cruthaithe:	Frontiers Media S.A. 2021-04-01
Sraith:	Frontiers in Immunology
Ábhair:	matrine multiple sclerosis bioinformatics network pharmacology IL10RA
Rochtain ar líne:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.640778/full

Míreanna comhchosúla

Research progress on the pharmacological effects of matrine
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Matrine Is Identified as a Novel Macropinocytosis Inducer by a Network Target Approach
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Matrine Exerts Pharmacological Effects Through Multiple Signaling Pathways: A Comprehensive Review
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The potential therapeutic value of the natural plant compounds matrine and oxymatrine in cardiovascular diseases
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Matrine Inhibits CNS Autoimmunity Through an IFN-β-Dependent Mechanism
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Matrine Impairs Platelet Function and Thrombosis and Inhibits ROS Production
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Matrine alleviates paraquat-induced pulmonary fibrosis in mouse models
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Synthesis, Characterization and Activity Evaluation of Matrinic Acid Derivatives as Potential Antiproliferative Agents
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Foilsithe / Cruthaithe: (2013-05-01)

Antiviral Effect of Matrine against Human Enterovirus 71
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Foilsithe / Cruthaithe: (2012-08-01)

Matrine induces V-ATPase-dependent cytoplasmic vacuolation and inhibits the function of the lysosome in leukemia cells
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Matrine Restrains Cell Growth and Metastasis by Up-Regulating LINC00472 in Bladder Carcinoma
de réir: Li L, et al.
Foilsithe / Cruthaithe: (2020-02-01)

Improvement of the Thermal Stability and Aqueous Solubility of Three Matrine Salts Assembled by the Similar Structure Salt Formers
de réir: Yeyang Wang, et al.
Foilsithe / Cruthaithe: (2024-01-01)

Development of a Novel Electrochemical Sensor for Determination of Matrine in Sophora flavescens
de réir: Junping Zhang, et al.
Foilsithe / Cruthaithe: (2017-04-01)

Zein nanoparticles stabilized by hydrophilic small molecule stabilizer matrine deliver curcumin effectively
de réir: Hong Liu, et al.
Foilsithe / Cruthaithe: (2023-01-01)

Matrine Promotes Human Myeloid Leukemia Cells Apoptosis Through Warburg Effect Mediated by Hexokinase 2
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Foilsithe / Cruthaithe: (2019-09-01)

Matrine promotes mitochondrial biosynthesis and reduces oxidative stress in experimental optic neuritis
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Foilsithe / Cruthaithe: (2022-09-01)

Matrine: A Promising Natural Product With Various Pharmacological Activities
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Foilsithe / Cruthaithe: (2020-05-01)

Matrine relieved DHAV-1-induced hepatocyte excessive interferon and pyroptosis by activating mitophagy
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Matrin3: Disorder and ALS Pathogenesis
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Foilsithe / Cruthaithe: (2022-01-01)

Design, Synthesis and Various Bioactivity of Acylhydrazone-Containing Matrine Analogues
de réir: Wanjun Ni, et al.
Foilsithe / Cruthaithe: (2023-05-01)

RETRACTED: Matrine Protects Cardiomyocytes Against Hyperglycemic Stress by Promoting Mitofusin 2-Induced Mitochondrial Fusion
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Foilsithe / Cruthaithe: (2021-02-01)

Synthesis of Halopyrazole Matrine Derivatives and Their Insecticidal and Fungicidal Activities
de réir: Xingan Cheng, et al.
Foilsithe / Cruthaithe: (2022-08-01)

Matrine Enhances the Pathogenicity of Beauveria brongniartii Against Spodoptera litura (Lepidoptera: Noctuidae)
de réir: Jianhui Wu, et al.
Foilsithe / Cruthaithe: (2019-08-01)

Self-Assembly of Rhein and Matrine Nanoparticles for Enhanced Wound Healing
de réir: Xunxun Wu, et al.
Foilsithe / Cruthaithe: (2024-07-01)

Matrine family derivatives: Synthesis, reactions procedures, mechanism, and application in medicinal, agricultural, and materials chemistry
de réir: Jamal A.H. Kowah, et al.
Foilsithe / Cruthaithe: (2023-04-01)

The Effects of Matrine in Combination with Docetaxel on Castration-Resistant (Androgen-Independent) Prostate Cancer
de réir: Li Q, et al.
Foilsithe / Cruthaithe: (2019-12-01)

14-Thienyl Methylene Matrine (YYJ18), the Derivative from Matrine, Induces Apoptosis of Human Nasopharyngeal Carcinoma Cells by Targeting MAPK and PI3K/Akt Pathways in Vitro
de réir: Mao Xie, et al.
Foilsithe / Cruthaithe: (2014-05-01)

Autophagy inhibition enhances Matrine derivative MASM induced apoptosis in cancer cells via a mechanism involving reactive oxygen species-mediated PI3K/Akt/mTOR and Erk/p38 signaling
de réir: Yuming Zou, et al.
Foilsithe / Cruthaithe: (2019-10-01)

Hepatoprotective effect of Matrine salvianolic acid B salt on Carbon Tetrachloride-Induced Hepatic Fibrosis
de réir: Gao Hong-Ying, et al.
Foilsithe / Cruthaithe: (2012-05-01)

The combined usage of Matrine and Osthole inhibited endoplasmic reticulum apoptosis induced by PCV2
de réir: Yinlan Xu, et al.
Foilsithe / Cruthaithe: (2020-10-01)

Matrine and icariin can inhibit bovine viral diarrhoea virus replication by promoting type I interferon response in vitro
de réir: Cai Dongjie, et al.
Foilsithe / Cruthaithe: (2024-03-01)

Formulation of Matrine Oil-Based Suspension Concentrate for Improving the Wetting of Droplets and Spraying Performance
de réir: Meng Li, et al.
Foilsithe / Cruthaithe: (2023-07-01)

Matrine, a potential c-Myc inhibitor, suppresses ribosome biogenesis and nucleotide metabolism in myeloid leukemia
de réir: Wang-Jing Zhong, et al.
Foilsithe / Cruthaithe: (2022-10-01)

Effect of Matrine on growth performance, gut health, and gut microbiota in chickens infected with avian pathogenic Escherichia coli
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