Combined intranasal and intramuscular parainfluenza 5-, simian adenovirus ChAdOx1- and poxvirus MVA-vectored vaccines induce synergistically HIV-1-specific T cells in the mucosa

Combined intranasal and intramuscular parainfluenza 5-, simian adenovirus ChAdOx1- and poxvirus MVA-vectored vaccines induce synergistically HIV-1-specific T cells in the mucosa

IntroductionThe primary goal of this work is to broaden and enhance the options for induction of protective CD8+ T cells against HIV-1 and respiratory pathogens.MethodsWe explored the advantages of the parainfluenza virus 5 (PIV5) vector for delivery of pathogen-derived transgenes alone and in combi...

Täydet tiedot

Bibliografiset tiedot
Päätekijät: Ashley C. Beavis, Edmund G. -T. Wee, Belkis M. Akis Yildirim, Nicola Borthwick, Biao He, Tomáš Hanke
Aineistotyyppi: Artikkeli
Kieli:English
Julkaistu: Frontiers Media S.A. 2023-07-01
Sarja:Frontiers in Immunology
Aiheet:
CD8+ T cells
HIV vaccine
ChAdOx1
MVA
PIV5
Linkit:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1186478/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1186478/full

Samankaltaisia teoksia