Combined intranasal and intramuscular parainfluenza 5-, simian adenovirus ChAdOx1- and poxvirus MVA-vectored vaccines induce synergistically HIV-1-specific T cells in the mucosa

Combined intranasal and intramuscular parainfluenza 5-, simian adenovirus ChAdOx1- and poxvirus MVA-vectored vaccines induce synergistically HIV-1-specific T cells in the mucosa

IntroductionThe primary goal of this work is to broaden and enhance the options for induction of protective CD8+ T cells against HIV-1 and respiratory pathogens.MethodsWe explored the advantages of the parainfluenza virus 5 (PIV5) vector for delivery of pathogen-derived transgenes alone and in combi...

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Bibliographic Details
Main Authors: Ashley C. Beavis, Edmund G. -T. Wee, Belkis M. Akis Yildirim, Nicola Borthwick, Biao He, Tomáš Hanke
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Immunology
Subjects:
CD8+ T cells
HIV vaccine
ChAdOx1
MVA
PIV5
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1186478/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1186478/full

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