Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway

Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway

Intestinal ischemia-reperfusion (I/R) injury is a life-threatening vascular emergency and has long been a disturbing problem for surgeons. Oxidative stress is considered a vital factor in I/R injury. Metformin has anti-oxidative properties and protects against I/R injury. The present study aimed to...

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Bibliographic Details
Main Authors: Yifan Jia, Ruixia Cui, Cong Wang, Yang Feng, Zeyu Li, Yingmu Tong, Kai Qu, Chang Liu, Jingyao Zhang
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Redox Biology
Subjects:
Intestinal I/R injury
Metformin
Pyroptosis
TXNIP
Online Access:http://www.sciencedirect.com/science/article/pii/S221323172030255X

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http://www.sciencedirect.com/science/article/pii/S221323172030255X

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