RNA Activators of Stress Kinase PKR within Human Genes That Control Splicing or Translation Create Novel Targets for Hereditary Diseases

RNA Activators of Stress Kinase PKR within Human Genes That Control Splicing or Translation Create Novel Targets for Hereditary Diseases

Specific sequences within RNA encoded by human genes essential for survival possess the ability to activate the RNA-dependent stress kinase PKR, resulting in phosphorylation of its substrate, eukaryotic translation initiation factor-2α (eIF2α), either to curb their mRNA translation or to enhance mRN...

Full description

Bibliographic Details
Main Author: Raymond Kaempfer
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:International Journal of Molecular Sciences
Subjects:
PKR activation
RNA splicing
translation
inflammatory cytokine genes
<i>IFNG</i> RNA
<i>TNF</i> RNA
Online Access:https://www.mdpi.com/1422-0067/25/2/1323

Internet

https://www.mdpi.com/1422-0067/25/2/1323

Similar Items