Insulin-like Growth Factor-1 and IGF Binding Proteins Predict All-Cause Mortality and Morbidity in Older Adults

Insulin-like Growth Factor-1 and IGF Binding Proteins Predict All-Cause Mortality and Morbidity in Older Adults

While the growth hormone/insulin-like growth factor-1 (GH/IGF-1) pathway plays essential roles in growth and development, diminished signaling via this pathway in model organisms extends lifespan and health-span. In humans, circulating IGF-1 and IGF-binding proteins 3 and 1 (IGFBP-3 and 1), surrogat...

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Bibliographic Details
Main Authors: William B. Zhang, Sandra Aleksic, Tina Gao, Erica F. Weiss, Eleni Demetriou, Joe Verghese, Roee Holtzer, Nir Barzilai, Sofiya Milman
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cells
Subjects:
IGF-1
IGFBP-3
IGFBP-1
older adults
longevity
health-span
Online Access:https://www.mdpi.com/2073-4409/9/6/1368

Internet

https://www.mdpi.com/2073-4409/9/6/1368

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