Prospective Study Investigating the Efficacy and Safety of a Scalp Cooling Device for the Prevention of Alopecia in Women Undergoing (Neo)Adjuvant Chemotherapy for Breast Cancer
The prevention of chemotherapy-induced alopecia still represents an urgent need for every day clinical practice. In this regard, this prospective single-center study included breast cancer (BC) patients who underwent a scalp cooling device (Dignicap<sup>®</sup>) during (neo)adjuvant chem...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/29/10/569 |
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| author | Luisa Carbognin Cristina Accetta Danilo Di Giorgio Paola Fuso Margherita Muratore Giordana Tiberi Francesco Pavese Tatiana D’Angelo Alessandra Fabi Diana Giannarelli Alba Di Leone Stefano Magno Giorgia Garganese Alejandro Martin Sanchez Daniela Andreina Terribile Gianluca Franceschini Riccardo Masetti Giovanni Scambia Ida Paris |
| author_facet | Luisa Carbognin Cristina Accetta Danilo Di Giorgio Paola Fuso Margherita Muratore Giordana Tiberi Francesco Pavese Tatiana D’Angelo Alessandra Fabi Diana Giannarelli Alba Di Leone Stefano Magno Giorgia Garganese Alejandro Martin Sanchez Daniela Andreina Terribile Gianluca Franceschini Riccardo Masetti Giovanni Scambia Ida Paris |
| author_sort | Luisa Carbognin |
| collection | DOAJ |
| description | The prevention of chemotherapy-induced alopecia still represents an urgent need for every day clinical practice. In this regard, this prospective single-center study included breast cancer (BC) patients who underwent a scalp cooling device (Dignicap<sup>®</sup>) during (neo)adjuvant chemotherapy with the aim to evaluate the efficacy and safety of this device in preventing alopecia. One hundred and seventy-eight patients (median age 43 years) were enrolled. The chemotherapy regimen included anthracycline and taxane-based chemotherapy (68.1%), docetaxel and cyclophosphamide (25.8%), anthracycline and taxane-based plus carboplatin (3.9%), and paclitaxel alone (2.2%). In 25.3% of cases, a dose dense schedule was used. Overall, the success rate was 68.0%: 100% in paclitaxel alone, 87.0% in docetaxel-cyclophosphamide, 59.5% in anthracycline and taxane, and 71.4% in the sequential regimen plus carboplatin group (anthracycline and taxane-based chemotherapy versus taxane-based chemotherapy, <i>p</i> ≤ 001. No difference in terms of hair preservation between dose-dense or standard schedule was found (<i>p</i> = 0.557). Early discontinuation of the scalp cooling was observed in 50 patients (28.1%). Although 138 patients (77.5%) experienced adverse events, 70.2% of patients were satisfied with this device. In conclusion, this large prospective study confirmed the helpful effect of the scalp cooling system in preventing alopecia in BC patients also undergoing sequential anthracyclines and taxane-based chemotherapy. |
| first_indexed | 2024-03-09T20:24:26Z |
| format | Article |
| id | doaj.art-94ed6c69ae5040409e2ad6a4962e5438 |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-09T20:24:26Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-94ed6c69ae5040409e2ad6a4962e54382023-11-23T23:40:15ZengMDPI AGCurrent Oncology1198-00521718-77292022-09-0129107218722810.3390/curroncol29100569Prospective Study Investigating the Efficacy and Safety of a Scalp Cooling Device for the Prevention of Alopecia in Women Undergoing (Neo)Adjuvant Chemotherapy for Breast CancerLuisa Carbognin0Cristina Accetta1Danilo Di Giorgio2Paola Fuso3Margherita Muratore4Giordana Tiberi5Francesco Pavese6Tatiana D’Angelo7Alessandra Fabi8Diana Giannarelli9Alba Di Leone10Stefano Magno11Giorgia Garganese12Alejandro Martin Sanchez13Daniela Andreina Terribile14Gianluca Franceschini15Riccardo Masetti16Giovanni Scambia17Ida Paris18Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, ItalyDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, ItalyGynecology and Breast Care Center, Mater Olbia Hospital, 07026 Olbia, ItalyDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, ItalyDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, ItalyDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, ItalyDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, ItalyDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, ItalyDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, ItalyFacility of Epidemiology and Biostatistics, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, ItalyDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, ItalyDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, ItalyGynecology and Breast Care Center, Mater Olbia Hospital, 07026 Olbia, ItalyDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, ItalyDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, ItalyDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, ItalyDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, ItalyDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, ItalyDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, ItalyThe prevention of chemotherapy-induced alopecia still represents an urgent need for every day clinical practice. In this regard, this prospective single-center study included breast cancer (BC) patients who underwent a scalp cooling device (Dignicap<sup>®</sup>) during (neo)adjuvant chemotherapy with the aim to evaluate the efficacy and safety of this device in preventing alopecia. One hundred and seventy-eight patients (median age 43 years) were enrolled. The chemotherapy regimen included anthracycline and taxane-based chemotherapy (68.1%), docetaxel and cyclophosphamide (25.8%), anthracycline and taxane-based plus carboplatin (3.9%), and paclitaxel alone (2.2%). In 25.3% of cases, a dose dense schedule was used. Overall, the success rate was 68.0%: 100% in paclitaxel alone, 87.0% in docetaxel-cyclophosphamide, 59.5% in anthracycline and taxane, and 71.4% in the sequential regimen plus carboplatin group (anthracycline and taxane-based chemotherapy versus taxane-based chemotherapy, <i>p</i> ≤ 001. No difference in terms of hair preservation between dose-dense or standard schedule was found (<i>p</i> = 0.557). Early discontinuation of the scalp cooling was observed in 50 patients (28.1%). Although 138 patients (77.5%) experienced adverse events, 70.2% of patients were satisfied with this device. In conclusion, this large prospective study confirmed the helpful effect of the scalp cooling system in preventing alopecia in BC patients also undergoing sequential anthracyclines and taxane-based chemotherapy.https://www.mdpi.com/1718-7729/29/10/569alopeciabreast cancerchemotherapyscalp cooling |
| spellingShingle | Luisa Carbognin Cristina Accetta Danilo Di Giorgio Paola Fuso Margherita Muratore Giordana Tiberi Francesco Pavese Tatiana D’Angelo Alessandra Fabi Diana Giannarelli Alba Di Leone Stefano Magno Giorgia Garganese Alejandro Martin Sanchez Daniela Andreina Terribile Gianluca Franceschini Riccardo Masetti Giovanni Scambia Ida Paris Prospective Study Investigating the Efficacy and Safety of a Scalp Cooling Device for the Prevention of Alopecia in Women Undergoing (Neo)Adjuvant Chemotherapy for Breast Cancer Current Oncology alopecia breast cancer chemotherapy scalp cooling |
| title | Prospective Study Investigating the Efficacy and Safety of a Scalp Cooling Device for the Prevention of Alopecia in Women Undergoing (Neo)Adjuvant Chemotherapy for Breast Cancer |
| title_full | Prospective Study Investigating the Efficacy and Safety of a Scalp Cooling Device for the Prevention of Alopecia in Women Undergoing (Neo)Adjuvant Chemotherapy for Breast Cancer |
| title_fullStr | Prospective Study Investigating the Efficacy and Safety of a Scalp Cooling Device for the Prevention of Alopecia in Women Undergoing (Neo)Adjuvant Chemotherapy for Breast Cancer |
| title_full_unstemmed | Prospective Study Investigating the Efficacy and Safety of a Scalp Cooling Device for the Prevention of Alopecia in Women Undergoing (Neo)Adjuvant Chemotherapy for Breast Cancer |
| title_short | Prospective Study Investigating the Efficacy and Safety of a Scalp Cooling Device for the Prevention of Alopecia in Women Undergoing (Neo)Adjuvant Chemotherapy for Breast Cancer |
| title_sort | prospective study investigating the efficacy and safety of a scalp cooling device for the prevention of alopecia in women undergoing neo adjuvant chemotherapy for breast cancer |
| topic | alopecia breast cancer chemotherapy scalp cooling |
| url | https://www.mdpi.com/1718-7729/29/10/569 |
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