A STAT5-Smad3 dyad regulates adipogenic plasticity of visceral adipose mesenchymal stromal cells during chronic inflammation

A STAT5-Smad3 dyad regulates adipogenic plasticity of visceral adipose mesenchymal stromal cells during chronic inflammation

Abstract Adipogenic differentiation of visceral adipose tissue-resident multipotent mesenchymal stromal cells (VA-MSC) into adipocytes is metabolically protective. Under chronic inflammatory stress, this neoadipogenesis process is suppressed by various pro-inflammatory cytokines and growth factors....

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Bibliographic Details
Main Authors: Rahul Das, Jayeeta Giri, Pradyut K. Paul, Nicole Froelich, Raghavan Chinnadurai, Sara McCoy, Wade Bushman, Jacques Galipeau
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:npj Regenerative Medicine
Online Access:https://doi.org/10.1038/s41536-022-00244-5

Internet

https://doi.org/10.1038/s41536-022-00244-5

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