FOLFOX Therapy Induces Feedback Upregulation of CD44v6 through YB-1 to Maintain Stemness in Colon Initiating Cells

FOLFOX Therapy Induces Feedback Upregulation of CD44v6 through YB-1 to Maintain Stemness in Colon Initiating Cells

Cancer initiating cells (CICs) drive tumor formation and drug-resistance, but how they develop drug-resistance characteristics is not well understood. In this study, we demonstrate that chemotherapeutic agent FOLFOX, commonly used for drug-resistant/metastatic colorectal cancer (CRC) treatment, indu...

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Bibliographic Details
Main Authors: Shibnath Ghatak, Vincent C. Hascall, Roger R. Markwald, Suniti Misra
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
CD44v6
YB-1
MDR1
CIC
stemness genes
CD44v6 CRISPR/Cas9 knockout
Online Access:https://www.mdpi.com/1422-0067/22/2/753

Internet

https://www.mdpi.com/1422-0067/22/2/753

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