Dissecting nucleotide selectivity in viral RNA polymerases

Dissecting nucleotide selectivity in viral RNA polymerases

Designing antiviral therapeutics is of great concern per current pandemics caused by novel coronavirus or SARS-CoV-2. The core polymerase enzyme in the viral replication/transcription machinery is generally conserved and serves well for drug target. In this work we briefly review structural biology...

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Bibliographic Details
Main Authors: Chunhong Long, Moises Ernesto Romero, Daniel La Rocco, Jin Yu
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
RNA dependent RNA polymerase (RdRp)
RNA/DNA polymerase (RNAP/DNAP)
Fidelity control
Nucleotide selection
Molecular dynamics (MD) simulation
Kinetic modeling
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037021002361

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http://www.sciencedirect.com/science/article/pii/S2001037021002361

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