Imaging Sites of Inhibition of Proteolysis in Pathomimetic Human Breast Cancer Cultures by Light-Activated Ruthenium Compound.

The cysteine protease cathepsin B has been causally linked to progression and metastasis of breast cancers. We demonstrate inhibition by a dipeptidyl nitrile inhibitor (compound 1) of cathepsin B activity and also of pericellular degradation of dye-quenched collagen IV by living breast cancer cells....

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Main Authors: Suelem D Ramalho, Rajgopal Sharma, Jessica K White, Neha Aggarwal, Anita Chalasani, Mansoureh Sameni, Kamiar Moin, Paulo C Vieira, Claudia Turro, Jeremy J Kodanko, Bonnie F Sloane
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0142527