Degenerate mapping of environmental location presages deficits in object-location encoding and memory in the 5xFAD mouse model for Alzheimer's disease

Degenerate mapping of environmental location presages deficits in object-location encoding and memory in the 5xFAD mouse model for Alzheimer's disease

A key challenge in developing diagnosis and treatments for Alzheimer's disease (AD) is to detect abnormal network activity at as early a stage as possible. To date, behavioral and neurophysiological investigations in AD model mice have yet to conduct a longitudinal assessment of cellular pathol...

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Bibliographic Details
Main Authors: Hai Zhang, Lujia Chen, Kevin G. Johnston, Joshua Crapser, Kim N. Green, Nicole My-Linh Ha, Andrea J. Tenner, Todd C. Holmes, Douglas A. Nitz, Xiangmin Xu
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Neurobiology of Disease
Subjects:
Animal model
hippocampus
CA1
Object location memory
Spatial encoding
Disease progression
Online Access:http://www.sciencedirect.com/science/article/pii/S096999612200331X

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http://www.sciencedirect.com/science/article/pii/S096999612200331X

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