Disrupted autophagy and neuronal dysfunction in C. elegans knockin models of FUS amyotrophic lateral sclerosis

Disrupted autophagy and neuronal dysfunction in C. elegans knockin models of FUS amyotrophic lateral sclerosis

Summary: How mutations in FUS lead to neuronal dysfunction in amyotrophic lateral sclerosis (ALS) patients remains unclear. To examine mechanisms underlying ALS FUS dysfunction, we generate C. elegans knockin models using CRISPR-Cas9-mediated genome editing, creating R524S and P525L ALS FUS models....

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Bibliographic Details
Main Authors: Saba N. Baskoylu, Natalie Chapkis, Burak Unsal, Jeremy Lins, Kelsey Schuch, Jonah Simon, Anne C. Hart
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Cell Reports
Subjects:
ALS
FUS
autophagy
C. elegans
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721016995

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http://www.sciencedirect.com/science/article/pii/S2211124721016995

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