Linearolactone Induces Necrotic-like Death in <i>Giardia intestinalis</i> Trophozoites: Prediction of a Likely Target

Linearolactone Induces Necrotic-like Death in <i>Giardia intestinalis</i> Trophozoites: Prediction of a Likely Target

Linearolactone (LL) is a <i>neo</i>-clerodane type diterpene that has been shown to exert giardicidal effects; however, its mechanism of action is unknown. This work analyzes the cytotoxic effect of LL on <i>Giardia intestinalis</i> trophozoites and identifies proteins that c...

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Bibliographic Details
Main Authors: Raúl Argüello-García, Fernando Calzada, Bibiana Chávez-Munguía, Audifás-Salvador Matus-Meza, Elihú Bautista, Elizabeth Barbosa, Claudia Velazquez, Marta Elena Hernández-Caballero, Rosa Maria Ordoñez-Razo, José Antonio Velázquez-Domínguez
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Pharmaceuticals
Subjects:
<i>neo</i>-clerodane diterpenes
<i>Giardia intestinalis</i>
ROS production
ultrastructural alterations
docking analysis
aldose reductase
Online Access:https://www.mdpi.com/1424-8247/15/7/809

Internet

https://www.mdpi.com/1424-8247/15/7/809

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