Repurposing Cationic Amphiphilic Antihistamines for Cancer Treatment

Repurposing Cationic Amphiphilic Antihistamines for Cancer Treatment

Non-small cell lung cancer (NSCLC) is one of the deadliest cancers worldwide. In search for new NSCLC treatment options, we screened a cationic amphiphilic drug (CAD) library for cytotoxicity against NSCLC cells and identified several CAD antihistamines as inducers of lysosomal cell death. We then p...

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Bibliographic Details
Main Authors: Anne-Marie Ellegaard, Christian Dehlendorff, Anna C. Vind, Atul Anand, Luise Cederkvist, Nikolaj H.T. Petersen, Jesper Nylandsted, Jan Stenvang, Anders Mellemgaard, Kell Østerlind, Søren Friis, Marja Jäättelä
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416302572

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http://www.sciencedirect.com/science/article/pii/S2352396416302572

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