Inhibition of Gamma-Secretase Promotes Axon Regeneration After a Complete Spinal Cord Injury

Inhibition of Gamma-Secretase Promotes Axon Regeneration After a Complete Spinal Cord Injury

In a recent study, we showed that GABA and baclofen (a GABAB receptor agonist) inhibit caspase activation and promote axon regeneration in descending neurons of the sea lamprey brainstem after a complete spinal cord injury (Romaus-Sanjurjo et al., 2018a). Now, we repeated these treatments and perfor...

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Bibliographic Details
Main Authors: Daniel Sobrido-Cameán, Diego Robledo, Daniel Romaus-Sanjurjo, Vanessa Pérez-Cedrón, Laura Sánchez, María Celina Rodicio, Antón Barreiro-Iglesias
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
notch
gamma-secretase
axon regeneration
GABA
baclofen
RNA-Seq
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00173/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00173/full

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