Inter-epitope spacer variation within polytopic L2-based human papillomavirus antigens affects immunogenicity

Inter-epitope spacer variation within polytopic L2-based human papillomavirus antigens affects immunogenicity

Abstract The human papillomavirus minor capsid protein L2 is being extensively explored in pre-clinical studies as an attractive vaccine antigen capable of inducing broad-spectrum prophylactic antibody responses. Recently, we have developed two HPV vaccine antigens – PANHPVAX and CUT-PANHPVAX- both...

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Bibliographic Details
Main Authors: Yueru Zhang, Filipe Colaco Mariz, Peter Sehr, Gloria Spagnoli, Karl Moritz Koenig, Simay Çelikyürekli, Tim Kreuziger, Xueer Zhao, Angelo Bolchi, Simone Ottonello, Martin Müller
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-024-00832-0

Internet

https://doi.org/10.1038/s41541-024-00832-0

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