Targeting the SLIT/ROBO pathway in tumor progression: molecular mechanisms and therapeutic perspectives

The SLITs (SLIT1, SLIT2, and SLIT3) are a family of secreted proteins that mediate positional interactions between cells and their environment during development by signaling through ROBO receptors (ROBO1, ROBO2, ROBO3, and ROBO4). The SLIT/ROBO signaling pathway has been shown to participate in axo...

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Bibliographic Details
Main Authors: Zhengdong Jiang, Gang Liang, Ying Xiao, Tao Qin, Xin Chen, Erxi Wu, Qingyong Ma, Zheng Wang
Format: Article
Language:English
Published: SAGE Publishing 2019-06-01
Series:Therapeutic Advances in Medical Oncology
Online Access:https://doi.org/10.1177/1758835919855238