Substantial batch effects in TCGA exome sequences undermine pan-cancer analysis of germline variants

Substantial batch effects in TCGA exome sequences undermine pan-cancer analysis of germline variants

Abstract Background In recent years, research on cancer predisposition germline variants has emerged as a prominent field. The identity of somatic mutations is based on a reliable mapping of the patient germline variants. In addition, the statistics of germline variants frequencies in healthy indivi...

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Bibliographic Details
Main Authors: Roni Rasnic, Nadav Brandes, Or Zuk, Michal Linial
Format: Article
Language:English
Published: BMC 2019-08-01
Series:BMC Cancer
Subjects:
Cancer predisposition
TCGA
Germline variants
Batch effect
Somatic mutations
Personalized medicine
Online Access:http://link.springer.com/article/10.1186/s12885-019-5994-5

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http://link.springer.com/article/10.1186/s12885-019-5994-5

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