Alternation of Organ-Specific Exposure in LPS-Induced Pneumonia Mice after the Inhalation of Tetrandrine Is Governed by Metabolizing Enzyme Suppression and Lysosomal Trapping

Alternation of Organ-Specific Exposure in LPS-Induced Pneumonia Mice after the Inhalation of Tetrandrine Is Governed by Metabolizing Enzyme Suppression and Lysosomal Trapping

The objective of the present study was to define whether inhaled tetrandrine (TET) could be a promising way to achieve the local effect on its therapeutic efficacy based on biodistribution features using the LPS-treated acute lung injury (ALI) model. The tissue distribution profiles of inhaled TET i...

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Bibliographic Details
Main Authors: Furun Wang, Xue Jiang, Zengxu Yang, Shuang Fu, Shi Yao, Lingchao Wang, Yue Lv, Wenpeng Zhang, Rigao Ding, Xiaomei Zhuang
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
tetrandrine
inhalation
LPS
pulmonary inflammation
lung exposure
lysosomal trapping
Online Access:https://www.mdpi.com/1422-0067/23/21/12948

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https://www.mdpi.com/1422-0067/23/21/12948

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