RUNX1 overexpression triggers TGF-β signaling to upregulate p15 and thereby blocks early hematopoiesis by inducing cell cycle arrest

RUNX1 overexpression triggers TGF-β signaling to upregulate p15 and thereby blocks early hematopoiesis by inducing cell cycle arrest

p15INK4b (cyclin-dependent kinase inhibitor 2B, CDKN2B, p15), a cyclin-dependent kinase inhibitor (CKI) belonging to the INK4 family, plays an important role in hematopoiesis. Its expression level was positively related to the blockage effects of RUNX1b at the early stage. Experiments using human em...

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Bibliographic Details
Main Authors: Wencui Sun, Danying Yi, Lijiao Zhu, Jiahui Zeng, Yuanling Liu, Jing Chang, Jiawen Teng, Yonggang Zhang, Yong Dong, Xu Pan, Yijin Chen, Ya Zhou, Mowen Lai, Qiongxiu Zhou, Jiaxin Liu, Bo Chen, Feng Ma
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:Stem Cell Research
Subjects:
RUNX1/AML1
TGF-β signaling pathway
Hematopoiesis
Human embryonic stem cell (hESC)
P15
Cell cycle
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506122000435

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http://www.sciencedirect.com/science/article/pii/S1873506122000435

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