A simulation study investigating power estimates in phenome-wide association studies

A simulation study investigating power estimates in phenome-wide association studies

Abstract Background Phenome-wide association studies (PheWAS) are a high-throughput approach to evaluate comprehensive associations between genetic variants and a wide range of phenotypic measures. PheWAS has varying sample sizes for quantitative traits, and variable numbers of cases and controls fo...

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Bibliographic Details
Main Authors: Anurag Verma, Yuki Bradford, Scott Dudek, Anastasia M. Lucas, Shefali S. Verma, Sarah A. Pendergrass, Marylyn D. Ritchie
Format: Article
Language:English
Published: BMC 2018-04-01
Series:BMC Bioinformatics
Subjects:
PheWAS
EHR
ICD-9 codes
Power analysis
Simulation study
Online Access:http://link.springer.com/article/10.1186/s12859-018-2135-0

Internet

http://link.springer.com/article/10.1186/s12859-018-2135-0

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