Reducing IRF-1 to Levels Observed in HESN Subjects Limits HIV Replication, But Not the Extent of Host Immune Activation
Cells from women who are epidemiologically deemed resistant to HIV infection exhibit a 40–60% reduction in endogenous IRF-1 (interferon regulatory factor-1), an essential regulator of host antiviral immunity and the early HIV replication. This study examined the functional consequences of reducing e...
| Main Authors: | , , , , , , , , |
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| פורמט: | Article |
| שפה: | English |
| יצא לאור: |
Elsevier
2015-01-01
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| סדרה: | Molecular Therapy: Nucleic Acids |
| נושאים: | |
| גישה מקוונת: | http://www.sciencedirect.com/science/article/pii/S2162253116300440 |