DUSP-1 Induced by PGE<sub>2</sub> and PGE<sub>1</sub> Attenuates IL-1β-Activated MAPK Signaling, Leading to Suppression of NGF Expression in Human Intervertebral Disc Cells

DUSP-1 Induced by PGE<sub>2</sub> and PGE<sub>1</sub> Attenuates IL-1β-Activated MAPK Signaling, Leading to Suppression of NGF Expression in Human Intervertebral Disc Cells

The molecular mechanism of discogenic low back pain (LBP) involves nonphysiological nerve invasion into a degenerated intervertebral disc (IVD), induced by nerve growth factor (NGF). Selective cyclooxygenase (COX)-2 inhibitors are mainly used in the treatment of LBP, and act by suppressing the infla...

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Bibliographic Details
Main Authors: Takuya Kusakabe, Yasunobu Sawaji, Kenji Endo, Hidekazu Suzuki, Takamitsu Konishi, Asato Maekawa, Kazuma Murata, Kengo Yamamoto
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
dual-specificity phosphatase (DUSP)-1
prostaglandin E<sub>2</sub> (PGE<sub>2</sub>)
prostaglandin E<sub>1</sub> (PGE<sub>1</sub>)
interleukin-1β (IL-1β)
mitogen-activated protein kinase (MAPK)
nerve growth factor (NGF)
Online Access:https://www.mdpi.com/1422-0067/23/1/371

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https://www.mdpi.com/1422-0067/23/1/371

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