A Kinome RNAi Screen in Drosophila Identifies Novel Genes Interacting with Lgl, aPKC, and Crb Cell Polarity Genes in Epithelial Tissues

A Kinome RNAi Screen in Drosophila Identifies Novel Genes Interacting with Lgl, aPKC, and Crb Cell Polarity Genes in Epithelial Tissues

In both Drosophila melanogaster and mammalian systems, epithelial structure and underlying cell polarity are essential for proper tissue morphogenesis and organ growth. Cell polarity interfaces with multiple cellular processes that are regulated by the phosphorylation status of large protein network...

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Bibliographic Details
Main Authors: Linda M. Parsons, Nicola A. Grzeschik, Kasun Amaratunga, Peter Burke, Leonie M. Quinn, Helena E. Richardson
Format: Article
Language:English
Published: Oxford University Press 2017-08-01
Series:G3: Genes, Genomes, Genetics
Subjects:
cell polarity
Drosophila
phosphoprotein
kinase
phosphatase
Hippo
Wingless
Wnt
Ras
phosphoinositol
PI3K
nutrient sensing
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.117.043513

Internet

http://g3journal.org/lookup/doi/10.1534/g3.117.043513

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