Metabolic remodeling and calcium handling abnormality in induced pluripotent stem cell-derived cardiomyocytes in dilated phase of hypertrophic cardiomyopathy with MYBPC3 frameshift mutation

Metabolic remodeling and calcium handling abnormality in induced pluripotent stem cell-derived cardiomyocytes in dilated phase of hypertrophic cardiomyopathy with MYBPC3 frameshift mutation

Abstract Hypertrophic cardiomyopathy (HCM) is an inherited disorder characterized by left ventricular hypertrophy and diastolic dysfunction, and increases the risk of arrhythmias and heart failure. Some patients with HCM develop a dilated phase of hypertrophic cardiomyopathy (D-HCM) and have poor pr...

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Bibliografske podrobnosti
Main Authors: Haruka Mori, Dongzhu Xu, Yuzuno Shimoda, Zixun Yuan, Yoshiko Murakata, Binyang Xi, Kimi Sato, Masayoshi Yamamoto, Kazuko Tajiri, Tomoko Ishizu, Masaki Ieda, Nobuyuki Murakoshi
Format: Article
Jezik:English
Izdano: Nature Portfolio 2024-07-01
Serija:Scientific Reports
Teme:
Dilated phase of hypertrophic cardiomyopathy
Induced pluripotent stem cells
Myosin binding protein C
Cardiomyocytes
Energy metabolism
Online dostop:https://doi.org/10.1038/s41598-024-62530-0

Internet

https://doi.org/10.1038/s41598-024-62530-0

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