Structurally diverse brefeldin A derivatives as potent and selective acetylcholinesterase inhibitors from an endophytic fungus Penicillium brefeldianum F4a

Structurally diverse brefeldin A derivatives as potent and selective acetylcholinesterase inhibitors from an endophytic fungus Penicillium brefeldianum F4a

Nine previously undescribed brefeldin A (BFA) derivatives (1–9), together with one known compound 4-epi-brefeldin A (10), were isolated from an endophytic fungus Penicillium brefeldianum F4a. The chemical structures were elucidated using NMR and HRESIMS. ECD analysis and Mosher's method were us...

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Bibliographic Details
Main Authors: Yan Bai, Duo Ren, Xinlei Xue, Weixian Gao, Jiangchun Hu, Huaqi Pan
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Arabian Journal of Chemistry
Subjects:
Cholinesterase inhibitors
Endophytic fungi
Penicillium brefeldianum
Brefeldin A derivatives
Molecular docking
Online Access:http://www.sciencedirect.com/science/article/pii/S187853522300850X

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http://www.sciencedirect.com/science/article/pii/S187853522300850X

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