Structurally diverse brefeldin A derivatives as potent and selective acetylcholinesterase inhibitors from an endophytic fungus Penicillium brefeldianum F4a

Structurally diverse brefeldin A derivatives as potent and selective acetylcholinesterase inhibitors from an endophytic fungus Penicillium brefeldianum F4a

Nine previously undescribed brefeldin A (BFA) derivatives (1–9), together with one known compound 4-epi-brefeldin A (10), were isolated from an endophytic fungus Penicillium brefeldianum F4a. The chemical structures were elucidated using NMR and HRESIMS. ECD analysis and Mosher's method were us...

Full description

Bibliographic Details
Main Authors: Yan Bai, Duo Ren, Xinlei Xue, Weixian Gao, Jiangchun Hu, Huaqi Pan
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Arabian Journal of Chemistry
Subjects:
Cholinesterase inhibitors
Endophytic fungi
Penicillium brefeldianum
Brefeldin A derivatives
Molecular docking
Online Access:http://www.sciencedirect.com/science/article/pii/S187853522300850X

Similar Items

Similar Items