One-pot synthesis of (1RS,21SR)-diethyl 2-[23-amino-22-ethoxycarbonyl-8,11,14-trioxa-25-azatetracyclo[19.3.1.02,7.015,20]pentacosa-2,4,6,15(20),16,18,22-heptaen-25-yl]but-2-endioate

One-pot synthesis of (1RS,21SR)-diethyl 2-[23-amino-22-ethoxycarbonyl-8,11,14-trioxa-25-azatetracyclo[19.3.1.02,7.015,20]pentacosa-2,4,6,15(20),16,18,22-heptaen-25-yl]but-2-endioate

The title compound, C30H34N2O9 (4), is a product of the Michael reaction of azacrown ether with dimethyl acetylenedicarboxylate modified by an addition of NH3 (aq.) at 298 K. The aza-14-crown-4-ether ring adopts a bowl conformation. The dihedral angle between the planes of the benzene rings fused to...

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Bibliographic Details
Main Authors: Thi Thanh Van Tran, Tuan Anh Le, Hong Hieu Truong, Thi Nhung Dao, Anatoly T. Soldatenkov, Victor N Khrustalev
Format: Article
Language:English
Published: International Union of Crystallography 2018-09-01
Series:Acta Crystallographica Section E: Crystallographic Communications
Subjects:
macroheterocycles
azacrown ether
one-component reaction
cytotoxicity
anticancer activity
crystal structure
Online Access:http://scripts.iucr.org/cgi-bin/paper?S205698901801160X

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http://scripts.iucr.org/cgi-bin/paper?S205698901801160X

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