Evolocumab, a PCSK9‐Monoclonal Antibody, Rapidly Reverses Coronary Artery Endothelial Dysfunction in People Living With HIV and People With Dyslipidemia

Evolocumab, a PCSK9‐Monoclonal Antibody, Rapidly Reverses Coronary Artery Endothelial Dysfunction in People Living With HIV and People With Dyslipidemia

Background PCSK9 (proprotein convertase subtilisin/kexin type 9) is well recognized for its important role in cholesterol metabolism. Elevated levels are associated with increased cardiovascular risk and inhibition with PCSK9 antibodies (PCSK9i) lowers cardiovascular events in patients with coronary...

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Bibliographic Details
Main Authors: Thorsten M. Leucker, Gary Gerstenblith, Michael Schär, Todd T. Brown, Steven R. Jones, Yohannes Afework, Robert G. Weiss, Allison G. Hays
Format: Article
Language:English
Published: Wiley 2020-07-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
endothelial function
HIV
inflammation
magnetic resonance imaging
proprotein convertase subtilisin/kexin type 9
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.120.016263

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https://www.ahajournals.org/doi/10.1161/JAHA.120.016263

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