Endogenous siRNAs promote proteostasis and longevity in germline-less Caenorhabditis elegans

Endogenous siRNAs promote proteostasis and longevity in germline-less Caenorhabditis elegans

How lifespan and the rate of aging are set is a key problem in biology. Small RNAs are conserved molecules that impact diverse biological processes through the control of gene expression. However, in contrast to miRNAs, the role of endo-siRNAs in aging remains unexplored. Here, by combining deep seq...

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Bibliographic Details
Main Authors: Moran Cohen-Berkman, Reut Dudkevich, Shani Ben-Hamo, Alla Fishman, Yehuda Salzberg, Hiba Waldman Ben-Asher, Ayelet T Lamm, Sivan Henis-Korenblit
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-03-01
Series:eLife
Subjects:
endogenous siRNAs
aging
proteostasis
HSF1
germline
longevity
Online Access:https://elifesciences.org/articles/50896

Internet

https://elifesciences.org/articles/50896

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