The construction of modular universal chimeric antigen receptor T (MU-CAR-T) cells by covalent linkage of allogeneic T cells and various antibody fragments

The construction of modular universal chimeric antigen receptor T (MU-CAR-T) cells by covalent linkage of allogeneic T cells and various antibody fragments

Abstract Background Chimeric antigen receptor-T (CAR-T) cells therapy is one of the novel immunotherapeutic approaches with significant clinical success. However, their applications are limited because of long preparation time, high cost, and interpersonal variations. Although the manufacture of uni...

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Bibliographic Details
Main Authors: Tao Chen, Jieyi Deng, Yongli Zhang, Bingfeng Liu, Ruxin Liu, Yiqiang Zhu, Mo Zhou, Yingtong Lin, Baijin Xia, Keming Lin, Xiancai Ma, Hui Zhang
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Molecular Cancer
Subjects:
Universal CAR-T
Modular
SDcatcher/GVoptiTag
HIV-1
T cell lymphoma
Online Access:https://doi.org/10.1186/s12943-024-01938-8

Internet

https://doi.org/10.1186/s12943-024-01938-8

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