The Antianginal Drug Perhexiline Displays Cytotoxicity against Colorectal Cancer Cells In Vitro: A Potential for Drug Repurposing

The Antianginal Drug Perhexiline Displays Cytotoxicity against Colorectal Cancer Cells In Vitro: A Potential for Drug Repurposing

Colorectal cancer (CRC) is the second leading cause of cancer-related death worldwide. Perhexiline, a prophylactic anti-anginal drug, has been reported to have anti-tumour effects both in vitro and in vivo. Perhexiline as used clinically is a 50:50 racemic mixture ((R)-P) of (−) and (+) enantiomers....

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Bibliographic Details
Main Authors: Bimala Dhakal, Celine Man Ying Li, Runhao Li, Kenny Yeo, Josephine A. Wright, Krystyna A. Gieniec, Laura Vrbanac, Tarik Sammour, Matthew Lawrence, Michelle Thomas, Mark Lewis, Joanne Perry, Daniel L. Worthley, Susan L. Woods, Paul Drew, Benedetta C. Sallustio, Eric Smith, John D. Horowitz, Guy J. Maddern, Giovanni Licari, Kevin Fenix
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Cancers
Subjects:
perhexiline
colorectal cancer
patient-derived organoids
perhexiline enantiomers
anti-tumour agents
Online Access:https://www.mdpi.com/2072-6694/14/4/1043

Internet

https://www.mdpi.com/2072-6694/14/4/1043

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