Chemoenzymatic Protocol for the Synthesis of Enantiopure <i>β</i>-Blocker (<i>S</i>)-Bisoprolol

Chemoenzymatic Protocol for the Synthesis of Enantiopure <i>β</i>-Blocker (<i>S</i>)-Bisoprolol

The <i>β</i>-blocker (<i>S</i>)-bisoprolol hemifumarate has been synthesised in 96% enantiomeric excess with 19% total yield in a six-step synthesis. A transesterification reaction of the racemic chlorohydrin 1-chloro-3-(4-((2-isopropoxyethoxy)methyl)phenoxy)propan-2-ol catal...

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Bibliographic Details
Main Authors: Lucas Bocquin, Elisabeth Egholm Jacobsen
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Catalysts
Subjects:
(<i>S</i>)-bisoprolol
enantiopure building blocks
<i>Candida antarctica</i> lipase B
chiral chromatography
Online Access:https://www.mdpi.com/2073-4344/13/1/54

Internet

https://www.mdpi.com/2073-4344/13/1/54

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