Susceptibility of juvenile and adult blood–brain barrier to endothelin-1: regulation of P-glycoprotein and breast cancer resistance protein expression and transport activity

Susceptibility of juvenile and adult blood–brain barrier to endothelin-1: regulation of P-glycoprotein and breast cancer resistance protein expression and transport activity

<p>Abstract</p> <p>Background</p> <p>P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) play a critical role in keeping neurotoxic substances from entering the brain. We and others have previously reported an impact of inflammation on the regulation of ad...

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Bibliographic Details
Main Authors: Harati Rania, Villégier Anne-Sophie, Banks William A, Mabondzo Aloise
Format: Article
Language:English
Published: BMC 2012-12-01
Series:Journal of Neuroinflammation
Subjects:
Juvenile and adult blood–brain barrier
Neuroinflammation
Endothelin-1
Brain-to-blood transport
Drug transport
P-glycoprotein
Breast cancer resistance protein
Online Access:http://www.jneuroinflammation.com/content/9/1/273

Internet

http://www.jneuroinflammation.com/content/9/1/273

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