Sampling the conformational space of the catalytic subunit of human γ-secretase

Sampling the conformational space of the catalytic subunit of human γ-secretase

Human γ-secretase is an intra-membrane protease that cleaves many different substrates. Aberrant cleavage of Notch is implicated in cancer, while abnormalities in cutting amyloid precursor protein lead to Alzheimer's disease. Our previous cryo-EM structure of γ-secretase revealed considerable d...

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Bibliographic Details
Main Authors: Xiao-chen Bai, Eeson Rajendra, Guanghui Yang, Yigong Shi, Sjors HW Scheres
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-12-01
Series:eLife
Subjects:
electron microscopy
image analysis
gamma-secretase
Online Access:https://elifesciences.org/articles/11182

Internet

https://elifesciences.org/articles/11182

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