Recombinant human soluble thrombomodulin improved lipopolysaccharide/d-galactosamine-induced acute liver failure in mice

Recombinant human soluble thrombomodulin improved lipopolysaccharide/d-galactosamine-induced acute liver failure in mice

The effect of recombinant human soluble thrombomodulin (TM-α) on acute liver failure (ALF) is unclear, and we elucidated the effect of TM-α in lipopolysaccharide (LPS)/d-galactosamine (GalN)-induced ALF in mice. Placebo (saline) or TM-α (100 mg/kg) was administered 1 h after LPS/GalN administration....

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Bibliographic Details
Main Authors: Wataru Osumi, Denan Jin, Yoshiro Imai, Keitaro Tashiro, Zhong-Lian Li, Yoshinori Otsuki, Kentaro Maemura, Koji Komeda, Fumitoshi Hirokawa, Michihiro Hayashi, Shinji Takai, Kazuhisa Uchiyama
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:Journal of Pharmacological Sciences
Subjects:
Acute liver failure
High-mobility group box 1 protein
Thrombomodulin
Tumor necrosis factor-α
Nuclear factor-κB
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861315002297

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http://www.sciencedirect.com/science/article/pii/S1347861315002297

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