Conformational Heterogeneity and Cooperative Effects of Mammalian ALOX15

Conformational Heterogeneity and Cooperative Effects of Mammalian ALOX15

Arachidonic acid lipoxygenases (ALOXs) have been suggested to function as monomeric enzymes, but more recent data on rabbit ALOX15 indicated that there is a dynamic monomer-dimer equilibrium in aqueous solution. In the presence of an active site ligand (the ALOX15 inhibitor RS7) rabbit ALOX15 was cr...

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Bibliographic Details
Main Authors: Igor Ivanov, Alejandro Cruz, Alexander Zhuravlev, Almerinda Di Venere, Eleonora Nicolai, Sabine Stehling, José M. Lluch, Àngels González-Lafont, Hartmut Kuhn
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
lipoxygenases
crystal structure
protein–protein interactions
cooperative effects
molecular dynamics
Online Access:https://www.mdpi.com/1422-0067/22/6/3285

Internet

https://www.mdpi.com/1422-0067/22/6/3285

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