Morroniside attenuates nucleus pulposus cell senescence to alleviate intervertebral disc degeneration via inhibiting ROS-Hippo-p53 pathway

Morroniside attenuates nucleus pulposus cell senescence to alleviate intervertebral disc degeneration via inhibiting ROS-Hippo-p53 pathway

Intervertebral disc (IVD) degeneration (IVDD) which is highly prevalent within the elderly population, is a leading cause of chronic low back pain and disability. Nucleus pulposus (NP) cell senescence plays an indispensable role in the pathogenesis of IVDD. Morroniside is a major iridoid glycoside a...

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Bibliographic Details
Main Authors: Chengcong Zhou, Sai Yao, Fangda Fu, Yishan Bian, Zhiguo Zhang, Huihao Zhang, Huan Luo, Yuying Ge, Yuying Chen, Weifeng Ji, Kun Tian, Ming Yue, Hongting Jin, Peijian Tong, Chengliang Wu, Hongfeng Ruan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
intervertebral disc degeneration
morroniside
nucleus pulposus
cell senescence
hippo signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.942435/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.942435/full

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