Aberrant Methylation-Mediated Suppression of APAF1 in Myelodysplastic Syndrome

Aberrant Methylation-Mediated Suppression of APAF1 in Myelodysplastic Syndrome

Background: Myelodysplastic syndromes (MDSs) include a diverse group of clonal bone marrow disorders characterized by ineffective hematopoiesis and pancytopenia.It was found that down regulation of APAF1, a putative tumor suppressor gene (TSG),leads to resistance to chemotherapy and disease developm...

Full description

Bibliographic Details
Main Authors: Farhad Zaker, Nahid Nasiri, Naser Amirizadeh, Seyed Mohsen Razavi, Marjan Yaghmaie, Ladan Teimoori-Toolabi, Ali Maleki, Masoumeh Bakhshayesh
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2017-04-01
Series:International Journal of Hematology-Oncology and Stem Cell Research
Subjects:
HRM
Methylation
Myelodysplastic syndrome
APAF1
Online Access:https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/590

Internet

https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/590

Similar Items