PU.1 is required to restrain myelopoiesis during chronic inflammatory stress

PU.1 is required to restrain myelopoiesis during chronic inflammatory stress

Chronic inflammation is a common feature of aging and numerous diseases such as diabetes, obesity, and autoimmune syndromes and has been linked to the development of hematological malignancy. Blood-forming hematopoietic stem cells (HSC) can contribute to these diseases via the production of tissue-d...

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Bibliographic Details
Main Authors: James S. Chavez, Jennifer L. Rabe, Katia E. Niño, Harrison H. Wells, Rachel L. Gessner, Taylor S. Mills, Giovanny Hernandez, Eric M. Pietras
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
hematopoiesis
inflammation
myelopoiesis
PU.1
hematopoietic stem cell
hematopoietic progenitor cell
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1204160/full

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https://www.frontiersin.org/articles/10.3389/fcell.2023.1204160/full

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