Improvement of pristinamycin I (PI) production in Streptomyces pristinaespiralis by metabolic engineering approaches

Improvement of pristinamycin I (PI) production in Streptomyces pristinaespiralis by metabolic engineering approaches

Pristinamycin, produced by Streptomyces pristinaespiralis, which is a streptogramin-like antibiotic consisting of two chemically unrelated components: pristinamycin I (PI) and pristinamycin II (PII), shows potent activity against many antibiotic-resistant pathogens. However, so far pristinamycin pro...

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Bibliographic Details
Main Authors: Jiali Meng, Rongrong Feng, Guosong Zheng, Mei Ge, Yvonne Mast, Wolfgang Wohlleben, Jufang Gao, Weihong Jiang, Yinhua Lu
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2017-06-01
Series:Synthetic and Systems Biotechnology
Subjects:
Streptomyces pristinaespiralis
Pristinamycin I
Biosynthetic gene cluster
Metabolic engineering
Online Access:http://www.sciencedirect.com/science/article/pii/S2405805X17300509

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http://www.sciencedirect.com/science/article/pii/S2405805X17300509

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